Zaxone 250 injection contains ceftriaxone. It is an antibiotic which is used for the treatment of bacterial infections. It is a broad spectrum antibiotic which is active against gram positive bacteria and also active for gram negative.
Prevention of second meningococcal meningitis
50 mg/kg IM/IV or as directed by the physician
It produces its pharmacological action by binding to penicillin binding proteins which causes inhibition of final step of transpeptidation of peptidoglycon synthesis and causes cell death.
After administration the peak plasma concentration is achieving is achieving after 2hrs.
The drug is distributed widely into the body tissues and fluids. It also spreads to cerebrospinal fluid. The protein binding of the drug is about 85-95%.
After distribution the drug about 40-65% is excreted in unchanged form in urine. The elimination half life is 6-9 hrs.
Hypersensitivity to cephalosporins
Co administration of calcium or calcium containing products should not be use with ceftriaxone in 48hrs. This causes precipitation of calcium-ceftriaxone.
Only to be used when it is clearly needed
Transient elevation of BUN and serum creatinine
Can cause nephrotoxicity
Prolonged use can cause overgrowth of nonsusceptible organism
Regular analysis of the patient is required
Can displace bilirubin from serum albumin
Should not be administered to hyperbilirubinemic neonates, especially in prematures