Cefpodoxime Is A Cephalosporin Anti-Bitoic, It Is A Broad Spectrum Anti-Biotic And Is Used In The Treatment Of Various Bacterial Infections Especially Respiratory Tract Infections, Skin Infections And Urinary Tract Infections. Cefpodoxime Uses Include Treatment Of Bronchitis, Pneumonia, Gonorrhea , Tonsilitis, Sinusitis And Urinary Tract Infections.
Clavulanic acid is a ß-lactam drug that functions as a mechanism-based ß-Lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete ß-lactamase, which otherwise inactivates most penicillins.
- Acute Bacterial exacerbations of chronic bronchitis
- Acute maxillary Sinusitis
- Community acquired pneumonia
- Urinary Tract Infection
- Skin and Skin Structure Infection
- Acute otitis media
It is usually taken at intervals of 12 hours for 5 to 14 days.
Cefpodoxime Binds To One Or More Of The Penicillin-Binding Proteins (PBPs) Which Inhibits The Final Transpeptidation Step Of Peptidoglycan Synthesis In Bacterial Cell Wall, Thus Inhibiting Biosynthesis And Arresting Cell Wall Assembly Resulting In Bacterial Cell Death.
Absorption: Decreased Absorption In Conditions Of Low Gastric Acidity
Bioavailability: About 50%. Distribution: Respiratory And GU Tract (Therapeutic Concentrations), Enters Breast Milk (Low Concentrations). Protein-Binding: 20-30%.
Metabolism: De-Esterified To Cefpodoxime In The Intestinal Lumen.
Excretion: Via The Urine (As Unchanged); Removed By Dialysis; 2-3 Hr (Elimination Half-Life); Prolonged In Renal Impariment.
- History Of Allergy To Cefpodoxime
- Severe Renal Impairment