Zixif contains cefixime. It is a third generation cephalosporin antibiotic which is useful for the treatment of bacterial infections. It causes its effects by killing sensitive bacteria.
Bacterial infections
Otitis caused by Haemophilus influenza, Moraxella catarrhalis
Sinusitis
Tonsillitis
Pharyngitis caused by Streptococcus pyogenes
Bronchitis
Pneumonia caused by Streptococcus pneumonia
Once daily
Cefixime causes bactericidal action by inhibition of cell wall synthesis. It causes its action by binding to penicillin binding proteins i.e PBPs which causes inhibition of transpeptidation step in the peptidoglycon synthesis in the cell wall of bacteria. This causes inhibition of biosynthesis of cell wall and causes the bacterial cell death.
Absorption
After oral administration of the drug, about 40-50% is absorbed. The action of the drug is not affected presence of with or without food.
Distribution
Nearly about 65% of the drug is bound to plasma protein. The effect of the drug produced is concentration independent. The metabolism of the drug is through liver.
Excretion
Nearly about 50% of the absorbed dose is excreted in unchanged form in urine.
Allergic patients
Any allergic reaction towards cephalosporins
Previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs
Clostridium difficile associated diarrhea (CDAD) with the use of anti-bacterial agents
Reduces the activity of prothrombin
Should only be prescribed when clearly needed otherwise causes resistance to particular bacterial infection
