Zaxone TBZ contains ceftriaxone and tazobactum.
Ceftriaxone is an antibiotic which is used for the treatment of bacterial infections. It is a broad spectrum antibiotic which is active against gram positive bacteria
and also active for gram negative. Tazobactum is a pharmaceutical ingredient which is produces its action by inhibition of beta-lactamases.
Lower respiratory tract infections
Community acquired pneumonia
Acute bacterial otitis media
Urinary tract infections
Skin and skin structure infections
Pelvic inflammatory disease
Bacterial septicemia
Bone and joint infection
Intra-abdominal infections
Peri-operative prophylaxsis of infections associated with surgery
Bacterial meningitis
Intra-abdominal infections
50-75 mg/kg in every 12hrs or total dose should not exceed 2gm.
Ceftriaxone produces its action interfering with the biosynthesis of peptidoglycon which is required for bacterial cell. It also inactivates penicillin binding proteins.
Tazobactum is having beta lactamase inhibitory properties and have a penicillinic acid derivative sulphone derivative. It is active against beta-lactamase producing bacteria.
Absorption
The drug is effective against all organisms sensitive to ceftriaxone. Both the drug produces synergistic effect in combination.
Distribution
Ceftriaxone is about 98% bound to plasma proteins. It is also able to pass through blood brain barrier. 30% of the tazobactum is bound to plasma protein and the drug is widely distributed in body.
Excretion
The elimination half life of ceftrixone is about 8.7hrs. About 37-67% of the drug is removed in unchanged form.
Hypersensitivity to cephalosporins and beta-lactamase
Hyperbilirubinemic neonates, especially prematures
Penicillin allergy
Pseudomembranous colitis in patient with diarrhea
Analysis of prothrombin time in patients with impaired vitamin K synthesis
Prolong treatment causes overgrowth
Hyperbiolirubinemic neonates, mainly in prematures
Patient with history of GI diseases
