Zaxone – SB is a combination of ceftriaxone and sulbactum.
Ceftriaxone is an antibiotic which is used for the treatment of bacterial infections. It is a broad spectrum antibiotic which is active against gram positive bacteria
and also active for gram negative. Sulbactum is a beta-lactamase drug which is used in combination with beta-lactum antibiotic for inhibition of beta-lactamse.
Prevention of second meningococcal meningitis
20 to 50 mg/kg bodyweight once daily. The daily dose should not exceed 50 mg/kg.
Ceftriaxone is a beta-lactum antibiotic which belongs to beta-lactum class and causes bactericidal action. It produces its action by interfering with PBP mediated cell synthesis which causes cell lysis. It also posseses antibacterial activity, mainly against E.coli
Salbactum causes its action by binding irreversibly to beta-lactamases produced by gram positive and gram negative bacteria and protects the beta-lactum ring of ceftriaxone and protects the activity of ceftriaxone.
After administration the peak plasma concentration is achieving is achieving after 2hrs.
The drug is distributed widely into the body tissues and fluids. It also spreads to cerebrospinal fluid. The protein binding of the drug is about 85-95%.
After distribution the drug about 40-65% is excreted in unchanged form in urine. The elimination half life is 6-9 hrs.
After administration of the drug, the half-life is attained in 1hr.
The drug is well distributed in the body; the serum concentration is achieved in 1hr.
The drug is excreted through kidney in unchanged form.
Any allergy with cephalosporin antibiotic
Hypersensitivity to the penicillin may predispose the patient with the possibility of allergic cross reaction.
Patient with hypersensitivity to cephalosporin