Zaxone 250 injection

/Zaxone 250 injection
Zaxone 250 injection 2018-07-13T03:51:27+00:00

Zaxone 250 injection contains ceftriaxone. It is an antibiotic which is used for the treatment of bacterial infections. It is a broad spectrum antibiotic which is active against gram positive bacteria and also active for gram negative.

  • Bacterial infections

  • Serious infections

  • Surgical prophylaxis

  • Prevention of second meningococcal meningitis

  • Typhoid fever

50 mg/kg IM/IV or as directed by the physician

It produces its pharmacological action by binding to penicillin binding proteins which causes inhibition of final step of transpeptidation of peptidoglycon synthesis and causes cell death.

Absorption

After administration the peak plasma concentration is achieving is achieving after 2hrs.

Distribution

The drug is distributed widely into the body tissues and fluids. It also spreads to cerebrospinal fluid. The protein binding of the drug is about  85-95%.

Excretion

After distribution the drug about 40-65% is excreted in unchanged form in urine. The elimination half life is 6-9 hrs.

  • Hypersensitivity to cephalosporins

  • Hyperbilirubinaemic neonates

  • Co administration of calcium or calcium containing products should not be use with ceftriaxone in 48hrs. This causes precipitation of calcium-ceftriaxone.

  • Only to be used when it is clearly needed

  • Transient elevation of BUN and serum creatinine

  • Can cause nephrotoxicity

  • Prolonged use can cause overgrowth of nonsusceptible organism

  • Regular analysis of the patient is required

  • Can displace bilirubin from serum albumin

  • Should not be administered to hyperbilirubinemic neonates, especially in prematures

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