Rexotril syrup

/Rexotril syrup
Rexotril syrup 2018-07-12T10:59:55+00:00

Rexotril syrup is a combination of phenylephrine hydrochloride and chlorpheniramine maleate.

Phenylephrine hydrochloride belongs to phenethylamine class, a selective α1-adrenergic receptor agonist.  It is mainly used as decongestant. It decreases the heart rate through reflex bradycardia.

Chlorpheniramine maleate is a first generation alkylamine antihistamine. It is used in the prevention of symptoms of allergic conditions such as rhinitis and urticaria.

  • Reduces symptoms associated with upper respiratory tract allergies

  • Bronchial irritation

  • Relieves sneezing, running nose and watery eyes

  • Adjunct with antibiotic in sinusitis, tonsillitis and otitis media

5 to 10 ml of syrup every 3 to 6 h.

Phenylephrine hydrochloride

It acts on three types of α1 adrenergic receptor and these receptors are involved in maintenance of vascular tone which includes vasocontrictory effects. Its activation causes mobilization of Ca2+ from intracellular stores. Phenylephrine hydrochloride produces its action by action on peripheral vascular smooth muscle and decreases nasal congestion which leads to decreased edema and causes increase  in drainage of sinus cavities.

Chlorpheniramine maleate

It produces its action by binding to histamine H1 receptor which blocks the action of endogenous histamine which produces relief in symptoms associated with histamine.

Phenylephrine hydrochloride


After oral administration it is completely absorbed, the drugs bioavailability is affected due to first pass metabolism.


Nearly about 95% of the drug is bound to plasma protein. The drug is metabolized by liver. The peak serum concentration of the drug is achieving in 0.75-2hrs.


The elimination half life of the drug is 2.1 to 3.4 hours.

Chlorpheniramine maleate


After oral administration the drug is well absorbed in GI tract


About 72% of the drug is bound to plasma protein. The drug follows hepatic metabolism.


The elimination half life of the drug is 21-27 hours.

  • Hypersensitivity reaction to any of the ingredient of the product

  • Severe hypertension

  • Severe coronary artery disease

  • Narrow-angle glaucoma; urinary retention

  • Hyperthyroidism

  • Peptic ulcer

  • Asthma attack

  • MAOI therapy or for 2 week after stopping MAOI therapy

  • Newborn or premature infants

  • Severe coronary artery disease

  • Assess for allergy symptoms

  • Check the patient for nervousness, dizziness, and insomnia

  • Monitor children for antihistamine-induced excitability

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