Piprazo 1.125gm injection is an anti-bacterial agent, is used for treating several serious bacterial infections. It may also be used to prevent infections during surgery. It works by blocking the growth of the bacterial cell wall, which eventually kills the bacteria.
- Urinary tract infections
- Bone and joint infections
- Severe vaginal infections
- Stomach infections
- Skin infections
The following table summarises the treatment frequency and the dose per body weight for paediatric patients 2-12 years of age by indication or condition:
Neutropenic children with fever– 80 mg Piperacillin / 10 mg Tazobactam per kg body weight / every 6 hours
Complicated intra-abdominal infections– 100 mg Piperacillin / 12.5 mg Tazobactam per kg body weight / every 8 hours
Piperacillin has an antimicrobial activity against a wide range of Gm-ve organisms & against Gm+ve, tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. in combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria
Distribution: Piperacillin And Tazabactam: 30% Bound To Plasma Proteins. Widely Distributed Into Body Tissues And Fluids.
Metabolism: Piperacillin Metabolised To A Desethyl Metabolite. Tazobactam: Metabolised To A Single Metabolite That Lacks Pharmacological And Antibacterial Activities. Excretion: Half-Life Of Piperacillin And Tazobactam Ranges From 0.7-1.2 Hr.
Elimination: Elimianted Via Kidney By Glomerular Filtration And Tubular Secretion. Piperacillin: 68% Excreted Unchanged In Urine.Tazobactam: 80% Excreted Unchanged In Urine.
- severe allergic reaction to any other beta-lactam active substances
- Pregnancy And Lactation
- Pseudomembranous Colitis
- Renal Impairment.
- Increased Risk Of Bleeding Manifestations.