- Urinary tract infections
- Bone and joint infections
- Severe vaginal infections
- Stomach infections
- Skin infections
The following table summarises the treatment frequency and the dose per body weight for paediatric patients 2-12 years of age by indication or condition:
Neutropenic children with fever– 80 mg Piperacillin / 10 mg Tazobactam per kg body weight / every 6 hours
Complicated intra-abdominal infections– 100 mg Piperacillin / 12.5 mg Tazobactam per kg body weight / every 8 hours
Piperacillin has an antimicrobial activity against a wide range of Gm-ve organisms & against Gm+ve, tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. in combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria
Distribution: Piperacillin And Tazabactam: 30% Bound To Plasma Proteins. Widely Distributed Into Body Tissues And Fluids.
Metabolism: Piperacillin Metabolised To A Desethyl Metabolite. Tazobactam: Metabolised To A Single Metabolite That Lacks Pharmacological And Antibacterial Activities. Excretion: Half-Life Of Piperacillin And Tazobactam Ranges From 0.7-1.2 Hr.
Elimination: Elimianted Via Kidney By Glomerular Filtration And Tubular Secretion. Piperacillin: 68% Excreted Unchanged In Urine.Tazobactam: 80% Excreted Unchanged In Urine.
- severe allergic reaction to any other beta-lactam active substances
- Pregnancy And Lactation
- Pseudomembranous Colitis
- Renal Impairment.
- Increased Risk Of Bleeding Manifestations.