D3XT Drops

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D3XT Drops 2018-08-01T09:01:00+00:00

D3XT Drops contain Cholecalciferol (Vitamin D). It is a fat-soluble vitamin that helps your body absorbs calcium and phosphorus. Vitamin D drops are given to breast-fed infants because breast milk usually has low levels of vitamin D. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia, osteoporosis, hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It may be used in kidney disease to keep calcium levels normal and allow normal bone growth.

  • Bone disorders (such as rickets, osteomalacia)

  • Osteoporosis

  • calcium or phosphate disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia)

  • Kidney disease to keep calcium levels normal and allow normal bone growth.

The recommended dose is 400 to 1000 international units orally once a day.

By itself cholecalciferol is inactive. It is converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3). The second hydroxylation occurs mainly in the kidney through the action of CYP27B1 to convert 25-OH vitamin D3 into 1,25-dihydroxycholecalciferol (calcitriol, 1,25-(OH)2vitamin D3). All these metabolites are bound in blood to the vitamin D-binding protein. The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of proteins and is present in virtually every cell in the body.

Metabolism: liver, kidney.

Absorption: Vitamin D acts as a hormone and increases re-absorption of Calcium and Phosphorus by the kidneys and increased bone turnover

Excretion: bile primarily, urine;

Half-life: 14h (cholecalciferol), 10-21 days (25-hydroxyvitamin D3)

  • Acute alkalosis

  • Allergic reactions

  • Chronic copper toxicity

  • High blood calcium, blood pressure, calcium level

  • High levels affect zinc absorption

  • Hypersensitivity

  • Appendicitis

  • Beware that overdose causes enteritis, hepatitis, and nephritis

  • Blockage of intestines

  • Breastfeeding

  • Diarrhea

  • Do not take this medication if you are allergic to it

  • Heart problem

  • Kidney stones

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