Avox dry syrup contains amoxicillin and clavulanic acid. Avox is an oral antibiotic in which amoxicillin is a beta-lactamase inhibitor and clavulanate potassium is potassium salt of clavulanic acid. Amoxicillin is an analog of ampicillin and it is derived from penicillin nucleus. Clavulanic acid is a beta lactum which is structurally related to penicillin and it has the ability to inactivate some of the beta lactase by causing blocking of the active site of these enzymes.
Susceptible bacterial infections
Lower respiratory tract infections
Acute bacterial otitis media
Sinusitis
Skin and skin structure infections
Urinary tract infections
Every 12hr regimen is recommended with less or no diarrhea
Amoxicillin
Amoxicillin produces its action by binding to penicillin binding protein 1A which is present in the bacterial cell wall. Penicillin acylate the penicillin-sensitive transpepetidase C-terminal domain by opening the lactum ring. This causes inactivation of the enzyme which averts the formation of cross-link of two linear peptidoglycon strands. This inhibits the bacterila cell wall synthesis.
Clavulanic acid
It causes irreversibly inhibition of beta lactamse and causes restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria
Amoxicillin
Absorption
The drug after oral administration is rapidly absorbed
Distribution
About 20% of the drug is bound to plasma protein. The drug follows hepatic metabolism.
Excretion
The drug is excreted in unchanged form in urine.
Clavulanate potassium
Absorption
After oral administration the drug is 75% absorbed in the body.
Distribution
About 22 to 30% of the drug is bound to plasma protein. The metabolism of the drug is through liver.
Excretion
The drug is excreted through urin
In patients with the history of hypersensitivity reaction
Patient with the history of cholestatic jaundice
Hepatic dysfunction related to the drug
Hypersensitive reactions
Hepatic dysfunction
Clostridium difficile associated diarrhea (CDAD)
Erythematous skin rashes
In absence of suspected infection can cause drug resistance bacteria
