Avox- 228.5 Kid tablet Amoxicillin and clavulanic acid are antibiotics drugs belongs to penicillin group. These are the combination of antibiotics which are used for many infections. Amoxicillin is an analog of ampicillin and it is derived from penicillin nucleus. Clavulanic acid is a beta lactum structurally related to penicillin and inactivate the beta lactamase by blocking the active sites of these enzymes.
Susceptible bacterial infections
Lower respiratory tract infections
Acute bacterial totes media
Sinusitis
Skin and skin structure infections
Urinary tract infections
Avox- 228.5 Kid tablet 25-45 mg/kg /day divided doses every 12 hours.
Amoxicillin
Avox 228.5 kid tab is a combination of amoxicillin and clavulanic acid. It is a beta lactum structurally related to penicillin, it have the ability to block the active site of enzymes and causes inactivation of the wide variety of beta-lactumases. Clavulanic acid protects the amoxicillin from degradation.
Absorption
It is orally administered and well distributed in the body. The absorption analysis was made in pediatric patients as the concentration maximum of amoxicillin is 15.7±7.7 and for clavulanic acid it is 1.77±0.9.
Distribution
Both the component of avox does not bind highly with protein. About 25% of the amoxicillin is bound to human serum. 18% of the clavulanic acid is bound to serum.
Excretion
The drug is excreted in unchanged form in urine, about 50-70% of amoxicillin and 25-40% of clavulanic acid.
In patients with the history of hypersensitivity reaction
Patient with the history of cholestatic jaundice
Hepatic dysfunction related to the drug
Hypersensitive reactions
Hepatic dysfunction
Clostridium difficile associated diarrhea (CDAD)
Erythematous skin rashes
In absence of suspected infection can cause drug resistance bacteria
